Ingrid C. McCall, Laboratory Manager

• BS Microbiology, Javeriana University, Bogota, Columbia

• MPH - Emory University, School of Public Health

I am both a Lab Manager and a Collaborator.   In the former capacity, I manage the logistics of the laboratory, train and supervise the students, visitors and others doing the preparative work, sampling cultures and counting colonies and plaques, on the massive numbers of plates generated in our experiments.

 As a collaborator, to different extents I have been engaged in the experimental elements of almost all of the antibiotic and phage research projects being done by Bruce, and students, postdocs, and the visitors in our Lab.  During the few years, my primary contribution as a collaborator has been the studies we are doing on the pharmacodynamics of antibiotics in Escherichia coli and Staphylococcus aureus, and on the  mechanisms of action of antibiotics.  Currently, in collaboration with Fernando Baquero and David Weiss, we expanding the research we did on the relationship between ribosome numbers and the action of ribosome-targeting bacteriostatic antibiotics, [1] to consider the aminoglycosides, which also target ribosomes.   Of particular interest in this study is to elucidate the extent to which the killing of bacteria by this class of antibiotics is independent of the their effects on ribosomes and the rates and fidelity of translation. 

For information about our research, please contact me at icmccal@emory.edu

1- Levin, B.R., et al., A Numbers Game: Ribosome Densities, Bacterial Growth, and Antibiotic-Mediated Stasis and Death. MBio, 2017. 8(1). PDF

2 - McCall, I.C., N. Shah, A. Govindan, F. Baquero, B.R. Levin (2019) Antibiotic killing of diversely generated populations of non-replicating bacteria, Antimicrobial Agents and Chemotherapy, Antimicrobial Agents and Chemotherapy. PDF